{"id":114,"date":"2012-06-03T20:55:31","date_gmt":"2012-06-04T00:55:31","guid":{"rendered":"https:\/\/nano.syr.edu\/?page_id=114"},"modified":"2012-07-26T23:48:16","modified_gmt":"2012-07-27T03:48:16","slug":"encoded-nanocarriers","status":"publish","type":"page","link":"https:\/\/nano.syr.edu\/?page_id=114","title":{"rendered":"Encoded Nanocarriers"},"content":{"rendered":"<p><a href=\"https:\/\/nano.syr.edu\/wp-content\/uploads\/2012\/07\/nanocarrier2.jpg\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" class=\"aligncenter size-large wp-image-282\" height=\"164\" src=\"https:\/\/nano.syr.edu\/wp-content\/uploads\/2012\/07\/nanocarrier2-1024x289.jpg\" title=\"nanocarrier2\" width=\"584\" srcset=\"https:\/\/nano.syr.edu\/wp-content\/uploads\/2012\/07\/nanocarrier2-1024x289.jpg 1024w, https:\/\/nano.syr.edu\/wp-content\/uploads\/2012\/07\/nanocarrier2-300x84.jpg 300w, https:\/\/nano.syr.edu\/wp-content\/uploads\/2012\/07\/nanocarrier2-500x141.jpg 500w, https:\/\/nano.syr.edu\/wp-content\/uploads\/2012\/07\/nanocarrier2.jpg 1900w\" sizes=\"auto, (max-width: 584px) 100vw, 584px\" \/><\/a><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size:16px;\"><span style=\"font-family: arial,helvetica,sans-serif;\">In collaboration with <a href=\"http:\/\/chemistry.syr.edu\/faculty\/dabrowiak.html\">Prof. Dabrowiak <\/a>and led by graduate student Colleen Alexander, we are exploring a new class of nanoscale drugs, which we call encoded nanocarriers.&nbsp; The basis for this project is inspired by work done on determining the mechanism for toxicity of some classes of chemotherapy drugs.&nbsp; Some drugs, like doxorubicin (DOX) bind to DNA in the nucleus with a surprisingly specific intercalation mechanism.&nbsp; With this intercalation model in mind, we designed and constructed a DNA-capped gold nanoparticle with a DNA code that contains three of these high affinity sites as shown above.&nbsp; Since we can tailor the code (i.e. sequence), length, and number of dsDNA at each nanoparticle, we term these materials as encoded.&nbsp; Next, the drug, like DOX, is incubated with the dsDNA-nanoparticle construct, and the drug loads itself into the dsDNA structure via intercalation, thus becoming a carrier of the drug.<\/span><\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size:16px;\"><span style=\"font-family: arial,helvetica,sans-serif;\">We recently showed the <a href=\"http:\/\/asnews.syr.edu\/newsevents_current\/News\/cancer_drug_nanoparticles.html\">proof-of-concept <\/a>of this approach in <a href=\"http:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2011\/cc\/c0cc04916f\"><em>Chemical Communications<\/em>.<\/a> &nbsp;Recent results have leveraged the capabilities of the Syracuse Biomaterials Institute for further understanding and in-depth cytotoxicity studies, which will be reported soon.<\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In collaboration with Prof. Dabrowiak and led by graduate student Colleen Alexander, we are exploring a new class of nanoscale drugs, which we call encoded nanocarriers.&nbsp; The basis for this project is inspired by work done on determining the mechanism &hellip; <a href=\"https:\/\/nano.syr.edu\/?page_id=114\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-114","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/nano.syr.edu\/index.php?rest_route=\/wp\/v2\/pages\/114","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nano.syr.edu\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/nano.syr.edu\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/nano.syr.edu\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/nano.syr.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=114"}],"version-history":[{"count":4,"href":"https:\/\/nano.syr.edu\/index.php?rest_route=\/wp\/v2\/pages\/114\/revisions"}],"predecessor-version":[{"id":289,"href":"https:\/\/nano.syr.edu\/index.php?rest_route=\/wp\/v2\/pages\/114\/revisions\/289"}],"wp:attachment":[{"href":"https:\/\/nano.syr.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=114"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}